Endocrine Abstracts

Mutations in the AIP gene have been linked to familial cases of pituitary adenomas (Vierimaa et al, 2006). Analysis of the protein support its role as a tumour suppressor since mutations cause a loss-of-function with reduced protein interactions and over-expression of wild-type (WT) AIP reduces cell proliferation (Leontiou et al, 2008). AIP interacts with a number of interesting proteins, among them are the phosphodiesterases, PDE4A5 and PDE2A, the G proteins, Gαq and G&#...

Context: Epidemiological data is important to correctly quantify the extent of disease and needed health care resources. There are no reports on both incidence and prevalence rates for pituitary adenomas (PAs) together in the same population.Objective: The objective of the study was to establish the prevalence and incidence of pituitary adenomas with in-depth analysis of their various subtypes in a well defined population.Design: T...

Background: We studied a cohort of hyperparathyroid patients in order to elucidate their clinical, laboratory, radiological and histological findings; the role of diagnostic imaging and concomitant thyroid pathologies.Method: 48 patients met our inclusion criteria for hypercalcaemic primary hyperparathyroidism (pHPT). We documented patients’ demographic data, symptomatology, associated conditions and treatment and analysed the work-up, management an...

Wnt developmental pathways, have been implicated in a number of cancers. Wnt signaling proteins activate the B-catenin transcription factor which induces transcription of the oncogenes Cyclin D1 and Myc (Luo et al. 2007). Elston et al. (2008) found that Wnt inhibitors were down-regulated in pituitary tumours. Overexpression of Survivin, an inhibitor of apoptosis,correlates with poor prognosis and drug resistance (Altieri 2003, Ghosh et al. 20...